APOrtha Vitamin D3 10.000 IE + Vitamin K2 MK-7 Cyclo® 200 µg – 365 Tablets
365 tablets · 1 tablet every 10 days
LPSD2H
Product description
These tablets are designed as a high-dose depot combination: one tablet contains 10,000 IU vitamin D3 and 200 µg K2 MK-7 but is taken only every tenth day. This results in a relatively moderate average daily intake of 1,000 IU D3 and 20 µg K2. The product character clearly lies in the infrequent depot dosing.
Vitamin D3
1,000 IE per dayAssessment by Oliver Fröhner
Micronutrient expert & Food Coach
Product character
These tablets are designed as a high-dose depot combination: one tablet contains 10,000 IU vitamin D3 and 200 µg K2 MK-7 but is taken only every tenth day. This results in a relatively moderate average daily intake of 1,000 IU D3 and 20 µg K2. The product character clearly lies in the infrequent depot dosing. From an orthomolecular perspective, comparison should therefore use average daily values rather than the single dose.
Formula & transparency
- Ingredients list fully checked
- Without silicon dioxide according to the fully reviewed ingredient list
- Product data reviewed within the freshness period
Points to consider
- Microcrystalline cellulose is declared.
Data basis
- Quality/laboratory status is based on manufacturer information
Summary by Oliver Fröhner
These tablets are designed as a high-dose depot combination: one tablet contains 10,000 IU vitamin D3 and 200 µg K2 MK-7 but is taken only every tenth day. This results in a relatively moderate average daily intake of 1,000 IU D3 and 20 µg K2. The product character clearly lies in the infrequent depot dosing.
Manufacturer information and Oliver Fröhner’s editorial assessment are presented separately. Data checked: 18 Sep 2026.
Active ingredients & NRV
Active ingredients
Ingredients & additives
Cholecalciferol (100.000 IE/g) (45,5%), Füllstoff (mikrokristalline Cellulose), Vitamin K2 MK-7 Zubereitung (7%) (Beta-Cyclodextrin, Vitamin K2 MK-7), MCT-Pulver (mittelkettige pflanzliche Triglyceride), Presshilfe (Magnesiumcarbonat).
Directions & package
Take 1 tablet every 10 days with plenty of water. This corresponds on average to 1,000 IU vitamin D3 per day and 20 µg vitamin K2 per day.
365 tablets · 3,650 days
Quality, lab & sources
Lab status: Manufacturer information
Per tablet: 10,000 IU vitamin D3 and 200 µg vitamin K2 MK-7; taking one every 10 days corresponds to an average daily intake of 1,000 IU vitamin D3 and 20 µg vitamin K2. Microcrystalline cellulose is explicitly included.
Product data checked on 18 Sep 2026.
Micronutrient knowledge
Micronutrient knowledge
Physiological functions, notes on high or insufficient intake and relevant interactions — presented separately from the specific product assessment.
Vitamin D3
Vitamin D is a fat-soluble vitamin and also a precursor of hormonally active metabolites. For the assessment of supplements, product dose, dosing interval, total intake, 25-OH-vitamin-D status and safety limits are considered separately.
Functions
EU-authorised functions include, among other things: vitamin D contributes to normal absorption and utilisation of calcium and phosphorus, normal blood calcium levels, the maintenance of normal bones and teeth, normal muscle function and normal functioning of the immune system. Vitamin D also has a role in the process of cell division.
Possible signs of insufficient intake
Inadequate vitamin D status cannot be reliably identified from individual nonspecific symptoms. For individual assessment, 25-OH-vitamin-D status together with exposure, diet and supplemental intake is more informative than symptoms alone.
Points to consider at high intake
A markedly excessive vitamin D intake over a prolonged period can lead to hypercalcaemia and hypercalciuria and thereby place a burden on the kidneys and other organ systems. Upper Intake Levels are safety limits for long-term intake and are not optimal target values.
Special considerations
Particular caution is required, among other situations, with diseases or therapies that affect calcium metabolism or kidney function. High doses should not be derived solely from general target values.
Interactions / caution
Vitamin D can interact with certain medicines; relevant examples include drugs that affect calcium or vitamin D metabolism. With prolonged higher-dose use, individual medication should be taken into account.
Vitamin K2
Vitamin K2 belongs to the vitamin K family and includes various menaquinones such as MK-4 and MK-7. MK-7 is commonly used in food supplements. K1 and K2 should not be treated as generally equivalent, even though the authorised vitamin K functions apply to vitamin K as a whole.
Functions
EU-authorised functions: Vitamin K contributes to normal blood clotting and to the maintenance of normal bones.
Possible signs of insufficient intake
Insufficient vitamin K status can impair vitamin-K-dependent blood clotting. An individual assessment should not be based solely on nonspecific symptoms.
Points to consider at high intake
No numerical US UL has been established for vitamin K because of insufficient data and the comparatively low observed toxicity. This does not mean that unlimited dosing is safe, particularly in the presence of relevant medication.
Special considerations
Particular attention is required in people taking vitamin-K-antagonist anticoagulants. In this context, independently changing vitamin K intake is not advisable.
Interactions / caution
Vitamin K can interact clinically significantly with vitamin K antagonists such as warfarin, phenprocoumon and similar anticoagulants. During such therapy, vitamin K intake should only be changed in consultation with the treating medical team.
Scientific assessment
Studies, meta-analyses and randomized controlled trials on the active ingredient – explained clearly and linked to sources.
LPSD2H
The information is provided for factual classification of product and nutrient data. It does not replace medical diagnosis or individual treatment advice.
